Cancer drug and arthritis drug found to help hair grow back in lab mice

One drug used for cancer treatment and another used to treat arthritis patients have been found to help lab mice regrow their hair back, and it is being considered to work probably to reverse hair loss in humans, but this is under clinical analysis.

In a study published October 23 in the journal Science Advances, tofacitinib (Xeljanz) is used for treating rheumatoid arthritis and the other, ruxolitinib (Jakafi) is used to treat rare blood cancers; and they were found to help bald mice regrow their hair in lab settings.

According to Dr. Luis Garza, an associate professor of dermatology at Johns Hopkins School of Medicine, it is possible to use the ultimate product for hair loss regrowth after topically rubbing in into the skin, but he warned that more work and research need to be done to translate the results of the findings into a topical product which people can use to regrow their hair.

Researchers from Columbia University in New York City were able to test the both tofacitinib and ruxolitinib on lab mice, and some of them even had patches of human skin. The only issue is that it is not known at the moment the amount of the drugs humans would need to regrow their hair if the drugs are proven to work for such a purpose; simply because tests that work on lab mice may not always work on humans the same way.

Researchers have been analyzing a kind of hair loss caused by an autoimmune skin condition known as alopecia areata, and the drugs were found to promote hair recovery in both mice and humans in past studies.

Statistics from the American Academy of Dermatology say nearly 80 million Americans are having thinning hair or going bald, and where Rogaine among other products has been made for hair regrowth, it has not been as effective as people desire. The drug stimulates hair follicles to grow longer than the one men will systematic baldness experience – said Angela Christiano, associate professor of molecular dermatology at Columbia.

Both tofacitinib and ruxolitinib are JAK inhibitors, and they were tested to prove that they induce new hair growth in mice while also causing human hair follicles to grow more hair, meaning that further research needs to establish if the drugs can be applied to regrow all forms of hair loss.